The singer songwriter will perform at the venue on Tuesday March 28, to help raise money for the charity.
Ed says: "It’s an honour to be asked back by the Teenage Cancer Trust for their fundraising week of live gigs.
"It’s such an important cause and one that I’m extremely proud to be a part of. See you then and let’s raise loads of money for young people with cancer."
His career has reached new heights recently when he returned with two hit singles "Castle on the Hill" and "Shape of You" which charted at number one and two positions across the globe.
Ed's third studio album ÷ (divide) is set to be released on March 3, following on from this first two successful albums which he showcased at sold out shows at Wembley Stadium in 2015 .
The gig takes place just after his world tour kicks off in March which will give UK fans a glimpse of what to expect when he returns to the O2 arena in May for three shows.
The Teenage Cancer Trust needs to raise £20 million a year to ensure the seven 13 to 24 year olds who are diagnosed with cancer every day don't face it alone.
Ed joins other headliners including Olly Murs, The Who, Pet Shop Boys and Paul Weller who will perform across the week to help the important cause.
When do tickets go on sale?
Tickets for Ed's show go on sale at 9am on Friday February 17.
The other shows taking place across the week are on sale now .
Where can I buy tickets?
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