Murray saw off Canada's Vasek Pospisil 6-4 7-5 6-4 in the last eight on Wednesday to set up the exciting last-four clash with the Swiss.
The British No 1 has home advantage but 17-time grand slam champion Federer is adored by the SW19 faithful and loyalties could be split in the showdown.
"I hope I get good support on Friday," Murray said. "It's been the case throughout the whole event and every year that I played here.
"Roger's extremely popular everywhere he goes, so it might not be as partisan a crowd or atmosphere as some matches that I play here.
"But it will still be an excellent atmosphere. I'll still get a boost from the crowd, I'm sure."
Friday’s match will be the 23rd time the pair have faced off, Federer having won the last three of their contests, although Murray triumphed when they most recently met on grass at London 2012.
Federer has won it all in his glittering career but shows no signs of slowing down and the Brit reckons the tennis legend, who turns 34 next month, has a few years left in him yet.
"It could be three, four years at the rate he's going just now," Murray added.
"But it depends on a lot of things, if he wants to continue or not. The reasons he's still at the top is he has a pretty efficient game style and he's quite loose on the court.
"It's very impressive that he's managed to stay at the top of the game for so long, considering how long he's been at the top and how many matches he's played.
"He's won over a thousand matches and played over 1,200 matches. That's a lot of tennis."
Andy Murray's quarter-final win over Vasek Pospisil in pictures: