LUKE Moore's smart corkscrew header a minute after the dismissal of Chairboys skipper Stuart Lewis was enough to give the Dons their first win of the season.
Ref Gavin Ward took a moment to compose himself before brandishing the red card on 34 minutes, but seemed convinced a high challenge on George Porter near the touchline had been dangerous.
He may have been one of the few in the ground to agree – such was the general air of disbelief within the stadium about the severity of the punishment.
But the Dons were not about to look the gift horse in the mouth and barely 60 seconds later, Moore (pictured) guided a perfect stooping header inside the far post from a Callum Kennedy cross.
A clearly incensed Wanderers boss Gareth Ainsworth – a former hero of the Dons – sought out Ward as the officials trooped off at half time, shaking his head furiously in disbelief at the key decision of the match.
The Dons will feel a goal had been coming anyway. They built up a decent head of steam in the opening 20 minutes, with Porter's pace down the right and Michael Smith's presence up front causing problems for the Chairboys.
Matt Ingram did well to turn aside a Porter drive from inside the box after Luke Moore had found the winger at the back post and Porter also went close with a raking low cross-shot after bamboozling Charles Dunne with a couple of feints. The duel between the two an intriguing feature of the first half.
In between, Smith had a rasping close ranger blocked by Leon Johnson.
Dean Morgan fired one over after getting the better of Alan Bennett in an aerial tussle, and Jon-Paul Pittman drew a save from keeper Ross Worner, but Wycombe were mostly on the back foot.
Then came the sending off to cement the impression that this was destined to be the Dons' afternoon.
To their credit, Wycombe rolled up their sleeves and gave a far better account of themselves in the second half with 10 men than they had done with 11 in the first.
They did not exactly carve out a host of chances, but did press the Dons back and made life a little uncomfortable – Matt Spring, Jo Kuffour and Steven Craig all coming off the bench to add a little more potency.
By contrast, the home attacks dried up as the match became something of a stalemate and the Dons were grateful to hear the final whistle, even though they had had few alarms.
Smith had a chance to wrap up the points in injury time but was denied by a heroic block and sub Chris Arthur hit the crossbar seconds later with a neat shot with the outside of his left boot. But it did not matter.
AFC WIMBLEDON: Worner; Fuller, Bennett, Frampton, Kennedy; Porter (Arthur 81), Sweeney, Pell, Luke Moore (Francomb 90), Midson (Sheringham 75), Smith. Subs not used: Brown, Sammy Moore, Fenlon.
WYCOMBE: Ingram; McCoy, Stewart, Johnson, Dunne; Cowan-Hall, Scowen, Lewis, Wood (Spring h/t); Morgan (Craig 71), Pittman (Kuffour 71). Subs not used: Horlock, Hause, Kretzschmar, Arnold.