Portsmouth 1-0 AFC Wimbledon
A header from Ryan Taylor seven minutes into the second half was enough to sent AFC Wimbledon home pointless.
He put away a cross from Daniel Alfei and the Dons had no response.
Boss Neal Ardley made a triple substitution with under 20 minutes remaining in a bid to save the game - with Jack Midson, Chris Arthur and Kevin Sainte-Luce all thrown on.
They almost snatched a point, with Alan Bennett's point-blank header saved by Trevor Carson, while Luke Moore had a shot cleared off the line.
But Pompey held on to avenge a 4-0 defeat at Kingsmeadow back in November.
Line-up: Worner, Fenlon (Arthur 72), Morris, Antwi, Bennett, Jones, Francomb (Sainte-Luce 72), Moore, Hylton (Midson 72), Wyke, Moore.
Subs (not used): Pell, Brown, Oakley.