Fulham 0-1 Blackburn Rovers
Kit Symons's chances of getting the Fulham job on a full-time basis took a blow as Jordan Rhodes earned Blackburn the points.
The 43-year-old was placed in temporary charge on Thursday after Felix Magath was fired following a disastrous start to the campaign.
However, the Cottagers were forced to play for 45 minutes a man short after Shaun Hutchinson's reckless tackle on Lee Williamson earned the defender a straight red.
Symons made three changes to the side that lost at Nottingham Forest in midweek, with Bryan Ruiz brought in from the cold and Marcus Bettinelli and Lasse Vigen Christensen restored to the starting XI.
Ben Marshall blazed over for Blackburn early on while Rudy Gestede headed straight at Bettinelli.
At the other end, Ross McCormack saw an effort deflected wide and Hugo Rodallega went close from distance.
Jason Steele was almost left red faced when his clearance cannoned off Rodallega, but fortunately for the Blackburn keeper the ball spiralled away from his goal.
Fulham were dealt a big blow in first-half stoppage-time when Hutchinson was dismissed for a sickening tackle on Williamson, which saw the Rovers midfielder stretchered off.
Bettinelli was called into action after the break when he blocked Gestede’s close-range effort as the visitors looked to make their one-man advantage count.
And they took the lead just before the hour mark. Corry Evans’s shot deflected off Dan Burn into the path of Rhodes, who steered his shot into the corner from six yards.
The hosts rallied and almost levelled when Tim Hoogland played in McCormack, but Steele stuck out a leg to thwart to former Leeds frontman.
Rhodes came close to adding a second for Rovers when he rounded Bettinelli, only for Burn to race back to block his goalbound effort.
Hoogland flashed an effort narrowly past the post late on, but the Cottagers couldn't find a way back.
Fulham: Bettinelli, Hoogland, Hutchinson, Burn, Amorebieta, Ruiz (Williams 73), Parker, Christensen, Stafylidis (Roberts 83), Rodallega, McCormack.
Subs (not used): Kiraly, Bodurov, Dembele, Hyndman, Kavanagh.