Chelsea 3-1 Manchester United
Hat-trick hero Samuel Eto'o put Manchester United to the sword to make it a century of wins for Jose Mourinho in the Premier League.
The former Barcelona and Inter Milan striker rolled back the years to produce his best performance in a Blues shirt yet and pile the pressure on beleaguered United manager David Moyes.
Mourinho made two changes to the side that won 2-0 at Hull City last time out as Eto'o and Branislav Ivanovic were preferred to Ashley Cole and Fernando Torres.
New arrival Nemanja Matic, a £22million signing from Benfica this week, had to settle for a place on the bench.
The absence of Wayne Rooney and Robin van Persie was a major boost for the Blues.
United started on the front foot and warmed Petr Cech's gloves as early as the second minute when Ashley Young linked up well with Danny Welbeck and got his shot away.
Ramires was the first to test David de Gea at the other end, however the Brazilian midfielder scuffed his long-range strike and the Red Devils goalkeeper was able to gather.
There was nothing the Spaniard could do to prevent Eto'o opening the scoring though.
Jonny Evans' defensive header fell straight to the feet of the Cameroon international, who cut inside his man and his curling effort deflected off Michael Carrick and flew into the top corner.
Suddenly the momentum shifted. Chelsea were the aggressors and Eden Hazard and Willian were raiding down the channels and causing the away side all sorts of problems.
A mistake from John Terry almost allowed the visitors to draw level.
Adnan Januzaj's cross should have been meat and drink for the Chelsea skipper but his slip allowed Welbeck in on goal and he fired at Cech while under pressure from Cesar Azpilicueta.
But right before half-time Chelsea struck a hammer blow to David Moyes' men, Eto'o grabbing his second of the afternoon with a simple finish after Gary Cahill had played the ball across goal.
Scoring just before the break put Mourinho's side firmly in the driving seat and the game effectively over four minutes after the restart as Eto'o completed his hat-trick from close-range.
Moyes rang the changes as United searched for a lifeline, throwing on Javier Hernandez and Chris Smalling, while Chelsea added steel to the midfield by switching Oscar with John Obi Mikel.
A lapse in concentration from Cech, who dawdled on the ball in possession right on his own goal-line, however substitute Hernandez couldn't react quickly enough and the Blues keeper recovered.
Hernandez is normally so sharp in front of goal and he proved it by pulling one back for United as the game approached the final 10 minutes, stretching to knock home Phil Jones' wayward shot.
Torres replaced Eto'o, who was deservedly given a standing ovation, and there was a late debut for Matic to cap off a superb day for Mourinho's side as they coasted home at Stamford Bridge.
To make matters worse for Moyes, Nemanja Vidic was sent off in injury time for a clumsy challenge on Hazard.
CHELSEA: Cech, Ivanovic, Luiz, Ramires, Oscar (Mikel 68), Hazard, Willian (Matic 85), Cahill, Terry, Azpilicueta, Eto'o (Torres 79).
Subs (not used): Schwarzer, Cole, Lampard, Mata.