The game was originally meant to kick-off on Saturday September 26 but has been brought forward to a 7.45pm kick-off the night before.
The last time these two sides met was on Easter Monday in 2013 and Rangers found themselves 3-0 down after 41 minutes.
Adel Taarabt pulled a goal back before half-time and Loic Remy reduced the deficit to one with just under 40 minutes remaining.
Steve Sidwell was sent off with 12 minutes remaining and QPR threw everything at the Whites. They were denied though as Fulham held on, with the Hoops taking the drop at the end of the season.
They bounced back in 2014 as the Cottagers were relegated but were unable to extend their stay in the top flight, suffering relegation back to the Championship.
Rangers' previous trip to Craven Cottage in the Premier League was also on Sky and the Hoops suffered a humiliating 6-0 reverse against their west London foes.