The draw was made last week and Fulham will host the Premier League side, who currently sit in 11th place in the top flight with 18 points, at the Cottage on January 6 in a 3pm kick off.
The Cottagers have already played the Saints twice this season in behind-closed-doors friendlies, losing 2-0 before being thrashed 5-1 at Staplewood, but Jokanovic is looking forward to showing the fans how his side team compares to a Premier League side next month.
He said: "It's good, it's nice and different competition.
"Okay, we have many games before this competition but we play some preparation games against them and it's a great chances for us and our supporters to see how we can fight against a Premier League team.
"We play at home and it's the best cup competition in the world and we must respect this competition and we will push hard and try to pass into the next round."