GetWestLondon's Tim Street identifies three key battles that they think will go a long way to deciding the result at Griffin Park.
Andre Gray v Dan Burn
Having stepped up three divisions when he moved from Luton Town to Brentford in the summer, Gray started slowly at Brentford, and it did not help his cause that Scott Hogan, the man signed to be Brentford's man goal-getter, forced Gray to shoulder more of a burden up front.
However, four goals in the Bees' last three games, including a brace in their last outing against Millwall, had made the young striker very much Brentford's man of the moment.
The man trying to keep him under wraps will be a familar face to Bees fans. Dan Burn was on loan to Yeovil when he scores the opening goal in the Glovers' League One play-off final victory over Brentford at Wembley two years ago.
Since then, the £350k signing from Darlington has become a firm fixture in the Fulham back four, and since making his debut against Norwich City in the FA Cup last January, making 11 appearances as the Whites battled relegation from the Premier League, and playing a further 15 games so far this season, helping keep four clean sheets.
Jonathan Douglas v Scott Parker
Jonathan Douglas has probably been Brentford's player of the year so far, playing an important role sitting just in front of the back four, and his importance to the side was so evident that when he was suspended for last week's win at Millwall, there were fears that the Bees would suffer.
However, Toumani Diagouraga stepped into his boots superbly, continuing his own fine form since coming in from the cold - which is just as well, as with talks over a new deal for Douglas having stalled, the Frenchman may eventually be asked to take on the role on a permanent basis.
Douglas will be champing at the bit to get back into the side for now, however, while up against him will be former England international Scott Parker.
One of the few to survive the cull of last season's disastrous relegation from the Premier League for Fulham, Parker, who has 18 caps for his country, has been calming influence in the middle of the park for the Whites this season, especially in the turbulent times under Felix Magath.
Harlee Dean v Ross McCormack
The Brentford back four will be well aware of the threat posed by Ross McCormack, after the £11million signing from Leeds netted the winner when Fulham won 1-0 at Griffin Park in the Capital One Cup back in August.
That was McCormack's first goal of the season, and he has so far only managed to add four more in the Championship as he struggles to live up to his expensive price tag, but having been sent off against Wigan earlier this month, he did net in his last outing, the win over Huddersfield two weeks ago.
Trying to keep McCormack's lean spell going will be Harlee Dean, who played in that Capital One Cup defeat in what was a rare appearance at the start of the season, with Tony Craig being suspended.
Dean continued to play second fiddle to Craig and James Tarkowski until the latter picked up a suspension for his fifth yellow card of the season last month, but has kept his place this time following a string of impressive peformances.
Keep up to date with all the build-up, matchday and post-game reaction to Brentford v Fulham right here on GetWestLondon