The annual event, which attracts thousands of professional and amateur cyclists raising money for good causes, takes place on July 30.
Kensington and Chelsea Council expects the route to be similar to the 2016 cycle ride, and is giving advanced road closure warnings.
It expects Knightsbridge, Brompton Road, Cromwell Road (A4), King’s Road, Ashburnham Road, Cremorne Road, Cheyne Walk and Chelsea Embankment to be closed on the day.
A spokesperson for the council said: “ Last year, roads in Kensington and Chelsea were closed from 5am and reopened at about 8pm.
“Final details of timings and road closures for this year’s event are not confirmed but the route is likely to be the same as last year.”
Other surrounding local roads will also be affected and have limited access during the day, with additional disruption expected this year as a result of ongoing gas works on Fulham Road between Beaufort Street and Edith Grove.
This work cannot be suspended on the day of the event, but the council says it will work closely with National Grid and TfL to minimise the level of disruption.
Thousands of amateur cyclists will take part in the 100-mile bike ride, which also takes in other parts of the capital and Surrey.
Cllr Tim Coleridge, transport boss at the Royal borough, said: “Prudential RideLondon is really growing in popularity. It’s a huge event involving thousands of cyclists of all abilities.
"With so many roads closed across London and the borough, the best way to minimise disruption is to put the date in your diary and plan ahead.
“I would urge any residents or community groups who have other plans on Sunday 30 July to check the event organiser and TfL’s websites for the latest information.”
Last year's Prudential RideLondon was marred when a cyclist collapsed and later died .
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