Hounslow officers took to Twitter asking anyone who may have seen Samuel Stephen Henderson to get in touch.
Police believe he may be in the Hounslow High Street area.
@MPSHounslow tweeted this message on Monday (August 22) afternoon: "Have you seen Samuel Stephen Henderson, aged 47 missing from Isleworth.
"May be around Hounslow High St. Call 101 quoting 17MIS037025."
Appeals are also in place for the public's help to find three other missing people from Brent and Ealing.
Samuel wears black frame glasses and has short curly dark blonde hair.
Anyone with information on Samuel's whereabouts is urged to call police on 101 and quote reference 17MIS037025.
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