The pair, a 16-year-old and a 17-year-old, were both charged with murder and possession of a pointed or bladed article.
They have not yet been named but are due to appear in custody at Hendon Magistrates' court on Saturday, 15 April.
The 16-year-old was arrested on Thursday April 13 and the 17-year-old on Friday April 14.
The charges relate to the stabbing in Newnham Close, Northolt, on Tuesday April 11.
Three 19-year-old men and an 18-year-old man who were initially arrested on suspicion of attempted murder and later arrested on suspicion of murder have been released under investigation, in line with new bail provisions.
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