The M4 will be closed until at least 6am on Thursday morning (October 13) following an earlier overturned lorry, according to Highways England.
An HGV crashed at around 12.51pm on Wednesday afternoon (October 12) spilling diesel across the motorway and causing delays expecting to last 10 hours, but authorities announced shortly before 7pm that the road would be closed overnight.
According to Thames Valley Police the driver of the lorry was taken to hospital suffering from 'serious injuries.'
A police statement said: “A truck overturned and the driver has been taken to hospital with serious injuries.
“This is following a collision on the westbound carriageway at about 12.45pm today.”
A diversion was put in place along the A404, M40 and A34.
Highways England announced the extended road closure on Twitter.
A statement said: “The HGV has spilled a large quantity of diesel onto the carriageway and shed its load of garden waste.
“The westbound carriageway will remain closed for several hours for recovery, clear-up and barrier damage repairs after the incident.
“Resurfacing of the carriageway by the fuel spill will also be carried out.”
The HGV crash is the second in the same stretch of road in two days, after a pedestrian was tragically killed in the early hours of Tuesday morning (October 11) after being involved in a collision.