Hammersmith Bridge will close to traffic during the October half-term to allow for essential repair work.
Engineers identified problems with the decking on the 130-year-old bridge, and will close it for six nights.
It comes ahead of planned major repairs of the bridge expected to be carried out by Transport for London (TfL) in July next year.
The bridge has closed on several occasions over recent years for urgent repairs .
The crossing will remain open for pedestrians and cyclists using it , with work chosen to take place over half term to reduce disruption and inconvenience.
The latest repair work, which will see the 130-year-old bridge closed to traffic and buses from 5pm on October 21 to the morning of October 27, will enable it to be used before the major repairs commence.
Motorists will be diverted via Chiswick Bridge and Putney Bridge, with buses also affected.
Passengers can walk across the bridge to resume their journeys.
For those less mobile, some 72 bus services will be diverted via Chiswick Bridge, the remainder will terminate ahead before Hammersmith Bridge.
Hammersmith and Fulham Council 's head of transport, Wesley Harcourt, said: “The safety of everyone using our historic bridge is our priority and regrettably these urgent repairs are essential to keeping the bridge safe and operational ahead of the major refurbishment work next year.
“We’re doing these works during half-term to minimise disruption to our residents, but appreciate that some people will still be affected.
“We want to give residents as much notice as possible to make alternative travel arrangements, or anticipate any delays.”
The bridge is currently operating under severe weight restrictions with only one bus in each direction permitted on the bridge at any one time.
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