Almost 2,000 homes are set to be built on the former GSK site in Greenford after the council granted the development permission.
It will include 1,965 residential units, a two-form entry primary school and nursery, shops, offices and leisure facilities in Greenford Road, formerly the GSK and J. Lyons site.
Plans were given the go-ahead by councillors at an Ealing Council planning committee meeting on Wednesday (March 15).
Of the residential units 1,439 will be available for rent, with 526 on sale, and will be 30% affordable overall.
Developers Greystar has promised an NHS-operated health centre, which will be delivered by Hillingdon & Ealing Clinical Commissioning Group (CCG).
This will be an out-of-hospital hub, a single building offering a range of services - including GP services, mental health and social care.
Greystar's managing director, Mark Allnut, said: "We are going to provide much needed homes for rent at a time when people are looking for a better renting experience.
"Greenford will be a diverse rental community for young professionals, families and older people."
Previously, Greystar had proposed 2,060 homes on the 20.3 acre area before it was reduced to 1,965.
The tallest building was also dropped from 24 storeys to 19.
It has been said the development will generate 1,205 full time jobs during its operational phase.
However, concerns have been raised over congestion in the area and there are fears the 837 car parking spaces will leave many residents without a spot.
Labour councillor Aysha Raza said the development would benefit the area, but stressed Greystar must do all it can to address these concerns.
Cllr Raza said: "It will be generating jobs, much needed housing - there are a lot of things.
"But at the same time we must make sure residents already living there are looked after too, that is where the hard work starts now.
"We must make sure Greystar are accountable for what they are promising us."
Greystar has previously said in a response to concerns raised by residents that the site is located within walking distance of public transport, has invested in walking an cycling facilities and had taken steps to reduce car ownership with the provision of a car club.
It hoped the whole development will be ready within six years, but Greystar said residents will start being able to move in by 2019.
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