Police were called by the London Ambulance Service (LAS) at 4.58am on Monday (December 14) to reports of a collision between a car and a motorcyclist in St Ann's Road at the junction with Swanscomb Road in Shepherd's Bush.
Officers attended along with LAS. The motorcyclist, a 52-year-old man, was pronounced dead at the scene.
Police await formal identification. Next of kin have been informed and a post-mortem examination will be scheduled in due course.
Detectives are keen to trace the driver of a Vauxhall Astra found abandoned at the scene.
As part of the investigation, detectives have released an image of a man they would like to speak to in connection with the collision. He is Darren February, 32, of North Kensington.
He is a black man with a beard. He is approximately 5ft 10ins tall and of slim build. He has a two inch scar above his left eye. No arrests have been made.
Detectives are appealing for anyone who may have witnessed the collision to call the incident room on 020 8247 6935, 101, or Crimestoppers on 0800 555 111.