Chelsea Embankment is closed to westbound traffic for a major gas mains replacement programme until April 2018.
The road closed between Chelsea Bridge and Battersea Bridge on 10pm on Sunday (November 26) and is expected to reopen in April 2018.
Pedestrians and cyclists will still have access to the road and a signed diversion has been set up to help drivers negotiate the detour.
The detour diverts traffic up Chelsea Bridge Road and through Sloane Street to the A4 at Brompton Road.
TfL has advised motorists to allow plenty of extra time for any journeys between 7am and 10am and 4pm and 7pm.
Westbound bus routes 170 and 360 will be operating on diversion for the duration of the works with some bus stops closed and westbound tour buses will also be diverted
Routes 11, 19, 22, 49, 211, 319, N11, N19 and N22 will not be diverted but may be subject to delays.
Cadent Gas, formerly known as National Grid Gas Distribution Limited, is co-ordinating the works with Tideway, which is building London's new "Super Sewer" , so that disruption on the road would be minimised.
Cadent engineering manager Stuart Donaldson said: “The gas mains we are replacing were laid when there was a lot less traffic on the road, however we’ve carefully designed this essential project to ensure there is as little impact as possible on the area.
“Coordinating the Cadent and Tideway work means an additional three-month road closure will not be needed
He added: “The new gas pipes will reduce the amount of unplanned repairs and maintenance needed on the gas network and the knock-on disruption that can cause for residents and road users.”
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