Old Oak and Park Royal, which includes land within the boroughs of Brent, Ealing and Hammersmith & Fulham, is set to become a major transport hub where High Speed 2 meets Crossrail, creating super-fast links in and out of the area.
Under the Mayor of London's proposals, it will also see the development of 25,500 new homes and 65,000 new jobs, delivered over the next 20 - 30 years.
The Old Oak and Park Royal Development Corporation, the body overseeing the regeneration, is now consulting on a draft 'Local Plan' document which sets out the mayor's vision for the area and the guidelines for how the site will develop over time.
A number of public events will be held during the consultation period to discuss the draft Local Plan, with the first drop in session and workshop taking place on February 11 at Harlesden Methodist Church in Brent.
Leader of Brent Council, Councillor Muhammed Butt, said: "Brent Council fully supports the regeneration of Old Oak and Park Royal because of the fantastic transport connections and large amount of new homes and jobs that will be created.
"There's no denying that the scale of transformation is huge. That's why we need to make sure, from the very outset, that the regeneration will help improve the lives of local people in Brent, especially around Harlesden and Willesden.
"Our main priority is always to secure the maximum benefit for our residents. We want to see as much affordable housing provided as possible and also ensure the very best outcome for Willesden Junction and Harlesden High Street.
"Given the scale of these proposals and the effect of the transformation on the wider area, I would urge everyone to go and have a look at the plans, give their feedback and help shape the future of Brent for the better. "
Sir Edward Lister, deputy mayor for planning and chairman of OPDC, said: "This is the first opportunity that West London residents and businesses have to contribute to the look and feel of the future Old Oak and Park Royal.
"With so much change planned it is vital that we receive the views of the local community so we can create an unrivalled new part of London."