The HMV store in The Chimes shopping centre in High Street will remain opening following a £50m buyout by Hilco.
The deal will save the store from any possible closure, along with 140 others across the UK, and save 2,500 jobs.
Hilco acquired HMV's Canadian operations two years ago, since when the performance of the business has surpassed expectations.
Paul McGowan, Hilco chief executive,told Sky News that the deal had the backing of key HMV suppliers and landlords.
He said: "We hope to replicate some of the success we have had in the Canadian market with the HMV Canada business which we acquired almost two years ago and which is now trading strongly.
"The structural differences in the markets and the higher level of competition in the UK will prove additional challenges for the UK business but we believe it has a successful future ahead of it."
It will be a boost to the Uxbridge economy following the closure of the Blockbuster store in Belmont Road earlier in the year