Wealdstone High Street has recently reopened to traffic after a decade's closure, but shop owners still face difficulties in trading.
While the opening of the road has gone some way to improving business, by increasing the visabilty of the businesses, traders are finding that shoppers are still going elsewhere.
Traders say the parking restrictions in the area are strangling commerce.
Mayoor Patel, from Saxons Motor Factors, complained that the council had painted double yellow lines outside his shop and put up CCTV, preventing people from stopping there.
Discussing the re-opening of the road he said: "It hasn't done much good; the damage has already been done."
Mr Patel said he is currently debating how long the company can continue trading in the area.
Tony Harvie, 52, owner of Northwest Electrics, who has been trading in Harrow for 32 years, has seen the effect the road closure has had on the local area.
"Wealdstone High Street is a very good spot," he said, "but they need to get it back to how it was before. The area looks better but it's only after a large failure."
Bhupendra Patel, who runs the newsagent Good News, told the Observer: "A lot of our customers are pensioners, and have to drive. There used to be free parking but now it's gone and they don't come because they have to pay.
"People have got used to a new routine, they have gone elsewhere and we are not getting any new customers because people don't know if the road has been opened or not. I don't know if it is going to get any better."
The road was re-opened at a ceremony last week attended by Wealdstone traders.
Councillor Paul Osborn (Conservative), portfolio holder for performance, communication and corporate services, said: "Following the work to improve Wealdstone High Street, there have been eight on-street parking spaces created.
"This was the maximum amount of spaces we were able to create, as we also had to ensure there were additional loading bays, bus stops and disabled parking.
"A consultation was held with traders in 2007 before the work on the High Street began. Parking was a key issue that was raised and by providing these additional spaces, we are responding to the wishes of traders and residents.
"Parking is available in the Peel House multi-storey car park, which can be accessed from Gladstone Way, providing in excess of 250 spaces."