Months of traffic chaos lie ahead as a busy route is closed for essential work.
From Monday, Cowley Mill Road will be blocked for up to five months for reconstruction of the approaches to the bridge over the Grand Union canal.
The route is busy, used by vehicles travelling to yards and industrial estates in the area.
But because the bridge is designated 'weak', large lorries must go around via Rockingham Road and St John's Road to access Uxbridge Industrial Estate and neighbouring trading estates. They will be joined by everyone else during the closure.
Traffic in Waterloo Road will also increase, as drivers are forced to find another way across the canal, which divides the town from routes to the west.
Pat Page, chairwoman of the Cowley Residents' Association, said: "It is going to be an absolute nightmare around here, and it is going to create even more chaos in Uxbridge.
"The roads will be in a right mess, people coming from the other way won't get in."
Last August, a lorry travelling to Wallingford Road on Uxbridge Industrial Estate overturned in St John's Road, flattening a bus stop and narrowly missing two young girls.
Mrs Page said: "There will be a lot of trouble in Rockingham Road. A school down there [St Mary's] has just had a zebra crossing put in because of all the lorries. It is waiting for a death down there.
"The accident back in August was waiting to happen, this is going to be really dangerous now."
Although she lives in Cleveland Road, some way from the bridge, Mrs Page fears a snarl up across the area.
"Along Cleveland Road it could be trouble for us. The lorries may come down here from The Greenway, there's no restrictions on lorries along here.
"Nobody will be able to go round the bridge to the Langley dump either."
Joe Poxon, who lives on Rockingham Road, said: "It's clear what the bridge closing means - everything is going to be coming round our way.
"It is a shame, and I think the council could have given more notice to people in Cowley and Uxbridge."
Cowley Mill Road is particularly busy on Fridays, as worshippers visit the Muslim community centre and hunt for places to park in neighbouring streets. Parking is allowed on one side of the road, meaning traffic must take turns to move in single file. The bridge is single file too, controlled by traffic lights with cameras.
Chris Norman, head of business services at Hillingdon Council, said the bridge would be closed from February 16 for up to five months, and diversions would be put in place to reduce congestion.
