A petition to stop the Milson Road Health Centre being closed and replaced with nine homes has so far attracted over 100 signatures.
It is planned to move services including district nursing, an ulcer clinic, podiatry and family planning to the White City Collaborative Care Centre in Bloemfontein Road - more than half an hour away by foot.
Residents say they are also concerned by the pace and nature of housing developments in the area. Two other schemes are planned in and around nearby Sinclair Road, with more than 140 flats set to be built.
Sinclair Gardens resident Adam Connell said: "Our local health service is being decimated. Moving these services half an hour away is unacceptable, and the area does not need these high-density luxury developments... I will campaign to oppose these proposals."
Labour councillor and health spokesman, Rory Vaughan said: "The Conservative run council is on course to give permission for the Milson Road Health Centre to be demolished and turned into an over-sized development of luxury flats and a private car park that is too big for this neighborhood and not wanted by local residents. We believe local people should be listened to and that the Milson Road Health Centre should remain as an important, modern NHS facility."
Andrew Pike, of the NHS Hammersmith and Fulham Clinical Commissioning Group, said: "We conducted a full consultation on the future of the building in September 2011 and I would ask anyone with concerns to get in contact with us.
"The building is quite old and would need substantial financial investment to bring it up to standard. All services are being moved locally, including to the new £13m facility in White City. We are making substantial investment in health services in the borough."
* Residents interested in signing the petition can contact local campaigners at firstname.lastname@example.org