London Scottish pulled off a real upset by knocking Manchester out of the EDF Energy Cup on their own turf on Saturday.
However, with Scottish unbeaten in National Three (South) and Manchester claiming just one win in National One,the two sides could well be meeting in National Two next season.
Tries from Roman Piotrowski and Simon Amor put Scottish in the driving seat before Manchester pulled back a penalty and a try.
But a Scottish penalty followed by a try for Charlie Broughton seemed to have Scottish home and dry, 22-8 up at half-time.
Manchester wasted no time in clawing themselves back with a try just two minutes after the interval, before an flurry of penalties left Scottish clinging to their lead.
Not for long though, as a converted try put Manchester in front for the first time with 10 minutes left.
But Owain Walybyoff secured Scottish's passage into the last 16 with the winning try.
Head coach Brett Taylor said: "This makes a statement about where we are as a team and shows we are ready for the next step."