Uxbridge's longest serving player has called time on his career at Honeycroft after 11 years.
Mark Weedon was the subject of a seven-day approach from divisional rivals Windsor & Eton, the current leaders of Southern League Division One South and West, and last week he opted to sign for the Royalists.
The central defender made 384 appearances for the Reds, scoring 11 goals in that time, but this season he has largely been sidelined with a longstanding knee problem and has played just one game, when Tony Choules made a raft of changes for the Middlesex Senior Cup tie with AFC Hayes.
"He expressed an interest to leave," said Choules. "We were very disappointed with that but we've never stood in people's way.
"He'll be a big loss to us because he was very instrumental in us getting into the play-offs last year.
"I rate Mark highly but when the seven-dayer came in from Windsor we couldn't compete with what they were offering.
"The door's always open for Mark, he's been a great servant to the club.
"He's always conducted himself very well. "He is going to be very hard to replace and I can see why Windsor came in for him."
Choules has made moves to strengthen his squad following the departures of Weedon and Mark Nicholls.
The manager has made seven-day approaches for four players from clubs in the same league and the level above and he will be able to speak to them on Monday.