Slavisa Jokanovic's side have had a season to remember and find themselves a win away from securing a play-off place, while Brentford have been in scintillating form themselves in the latter half of the season, with a 4-0 win over Derby and a 3-1 victory over QPR two of a long list of fine results.
Both sides boast some of the divisions best players, with Tom Cairney making the PFA Team of the Year thanks to his 11 goals and ten assists, while the return of Jota in January has boosted Brentford as a result of his 12 goals since coming back from Spain.
But who would make the cut in a combined XI?
Our Fulham reporter, Ryan O'Donovan, and Brentford correspondent, Tom Moore, have used our team selector to pick their combined XI ahead of the west London derby on Saturday and you can do the same by using it at the bottom of the article.
Ryan O'Donovan - Fulham reporter
Trying to pick a combined side between the two teams has thrown up a few headaches for me - yes, I know, my team doesn't contain Ryan Sessegnon who is by far and away the most exciting talent from both of the two teams but I have my reasonings for that.
The 16-year-old wouldn't make my XI because although he has monumental potential, he isn't the best player in his position yet - he still has a lot of growing to do but I have no doubt he will be one day.
Now that's out of the way, I can get down to business.
I've gone for Dan Bentley over Marcus Bettinelli on the basis that the Brentford keeper has been the number one all season and is one of the most talented goalkeepers in the entire league, whereas Marcus Bettinelli has only started regularly since the Ipswich game.
In defence I've gone for the entire back four of Fulham - Ryan Fredericks and Scott Malone provide so much going forward that I don't think you can put in Maxime Colin or Rico Henry over either of them, while I've been so impressed with Tim Ream and Tomas Kalas in recent weeks that I'd chose them over Harlee Dean or John Egan.
Tom Cairney is the automatic choice in midfield and is the best player on both sides in my books, while Stefan Johansen has been unbelievable going both forward and defensively and Celtic's loss has been Fulham's gain this year.
I'm a big fan of Ryan Woods, I like his passing range and his vision so he makes the midfield over Kevin McDonald, but by a margin.
Up top, Jota gets the right flank - he is an absolutely amazing player and Brentford have done well to get him back from his loan spell and into their side, I think he's definitely one of the best players in the division.
Meanwhile, I've gone for Floyd Ayite on the left who I've been really impressed with since his return for injury - his movement and skill has been key for Fulham and I think Brentford's back four will struggle with it on Saturday.
Lasse Vibe has been in great form since Brentford sold Scott Hogan and he gets the main striking role - it's something Fulham have been missing this season and I can't make any arguments against having a 15-goal striker in my team.
Tom Moore - Brentford reporter
Firstly, some of these decisions are easier than others. Certain players have been standouts on a regular basis making them locks in my team, while others have just been consistently good all season and where they share a position it means either could be selected.
Bentley would be my goalkeeper because he has had a fine season for Brentford between the sticks, while Marcus Bettinelli has spent most of it as number two to former Bee David Button.
Harlee Dean would partner Tomas Kalas at the heart of my defence. It's a difficult choice given the form of John Egan and, recently Yoann Barbet. The Brentford captain has been superb this season and I've always been a fan of the Chelsea youngster so I'd pair the two of them together.
Selecting a right back is the hardest decision for me. Maxime Colin and Ryan Fredericks have both had excellent seasons. Either would be a fine choice at right back but I've gone for the Frenchman.
Left back is a difficult choice but, much like the reasoning behind going for Bentley over Bettinelli, Scott Malone takes it over Rico Henry and Ryan Sessegnon.
Tom Cairney has to be in a combined team given his sensational form this campaign and only the most blinkered of Bees fans wouldn't have him in their XI.
I'd give him a free role in midfield with the pair of Ryan Woods and Kevin McDonald, who I feel has been just as important to Fulham as Cairney, sitting behind him to break play up before pushing forward once again.
Much like Cairney, Jota has to be in a combined team and only the most biased Whites fans would disagree.
To score 12 goals, while setting up a further five, since January as a wide player is sensational and any team would love to have the wing wizard on their side.
Sergi Canos of Floyd Ayite or Sone Aluko is a tough selection. I went for the Spaniard because he links up well with Lasse Vibe, who I'd have in my side over Chris Martin.
Who do you agree with? Use our team selector below and pick your side - don't forget to share it on social media with your friends.