A Tom Cairney first half goal and a Ryan Sessegnon double was enough to condemn Rafa Benitez' side to defeat, despite a late consolation goal from Daryl Murphy.
Fulham were by far the better side in the game and looked good value for their win, but Jokanovic insists his side are still going to continue fighting to make sure they're in the top six come the end of the season.
He said: "We are going to fight. We are not in position to be thinking about being a promoted team but we are thinking about pushing hard to push ourselves into the top six.
"If we are strong enough for the top six then we will have a 25% chance of being a Premier League team next season.
"It’s a great step for us, we must play ten more games and everything is open.
"Even though some teams at this moment have more points than what we have right now.
"On Tuesday night we are going to have another opportunity to fight for another three points and we must be ready to rest. Our minds must be rested and our bodies and we must be ready to fight again on Tuesday night."
16-year-old Sessegnon showed composure and talent well behind his years at St James' to score twice, and Jokanovic believes the youngster can be satisfied with his performance.
He sadded: "Sessegnon is working very well, we tried to use him in a little bit of a different position but in the past we have used him in more of an offensive position.
"We expected that he could find the space in behind the back four of Newcastle and he did that twice.
"He finished with a great level of quality and he completed a very good football game and he must be satisfied with the team and himself too."