Chelsea travel to Arsenal on Saturday evening seeking to continue their recent dominance after the Gunners.
The Blues have remained unbeaten in the league against the north London side since losing 5-3 in October 2011 - nearly a five year streak.
Antonio Conte's men will be looking to bounce back from last weekend's 2-1 defeat to Liverpool at Stamford Bridge .
First-half goals from Jordan Henderson and Dejan Lovren saw the Blues off last time out, despite a consolation strike from Diego Costa .
So will Conte's men be able to produce the goods again and get Chelsea's title charge back on track?
For the visitors, captain John Terry remains injured after the ankle knock he picked up in the 2-2 draw at Swansea two weeks ago.
Kurt Zouma is still expected to be out for three-four more weeks, but the Blues' injury woes end there.
And former Italy manager Conte refused to rule out playing two-goal hero Cesc Fabregas after his emphatic performance in at the King Power Stadium.
The hosts will give striker Olivier Giroud a late fitness test, while Aaron Ramsey remains injured with Per Mertesacker and Danny Welbeck not expected to be available to Arsene Wenger's men for the remainder of 2016.
Who wins this London derby?
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The duo are involved one of the most high-profile spats in the Premier League era, in a row stretching back to 2004.
Their contempt undoubtedly spread to their players on the pitch, and resulted in some bizarre matches.
Chelsea's 6-0 win in March 2014 springs to mind, when Kieran Gibbs was sent off in farcical style after just 15 minutes - with the Reds already 2-0 down.
And last season's 2-0 win for the Blues, again at Stamford Bridge, saw second-half goals from Kurt Zouma and Callum Chambers seal victory for Mourinho's men.
But that game saw the Reds competing with nine men after Gabriel Paulista was sent off after a clash with Diego Costa , and Santi Cazorla followed him 11 minutes from the end.
With Mourinho leaving the Blues not long after that clash clash though, will the match be as hot-tempered?
What we can expect today?
There's no Didier Drogba anymore, so the result is somewhat less obvious than it might have been a few years ago.
The Ivorian striker enjoyed scoring against the Gunners time and time again, but now that mantle may have been passed to Costa.
Chelsea's fiery forward enjoys the thrill of a fight, and knows how to get under the skin of defenders at the Emirates.
He did it last season, and Conte has got him back to his emphatic best so far this season, and in order to be at his best, Costa has to be angry.
Mourinho may no longer be with the Blues, but the scars left from those battles - and the rivalry between the fans - means the match will still be riveting to watch.
Red cards are likely, yellow cards are assured, and Chelsea probably have the upper-hand in terms of attacking quality.