Work on an extensive 'Railway Upgrade Plan' will begin on Christmas Eve once the last trains have run, and will continue until Monday, December 28.
The station will be open to allow access to London Underground Services.
The £150 million investment programme is said to deliver new station facilities, longer platforms, extra tracks, new junctions and thousands of pieces of more reliable equipment.
Overhead power lines between Acton and the Heathrow Airport junction will also be upgraded and foundations for overhead power lines between the junction to Heathrow Airport and Maidenhead will be installed.
Mark Langman, Network Rail ’s managing director for the Western route, said: “We have planned this upgrade work carefully to fit in as much as we can over the four non-work days that start on Christmas Day.
“That way we can minimise disruption for the millions of passengers who use the railway to get to work each day.
“The number of people travelling by rail continues to grow to record levels and this Christmas and New Year’s investment programme forms a key part of our Railway Upgrade Plan that is aimed at meeting surging demand and improving and expanding our congested railway network.”
Passengers planning to travel through the Thames Valley this Christmas and New Year period are advised to check before they travel through Great Western Railway's website or through National Rail Enquiries .