Around 35 firefighters and six fire engines were called to a fire at a derelict house in Willesden Lane, Willesden Green in the early hours of Wednesday (August 24) morning.
The London Fire Brigade were called at 1.38am and it took firefighters five hours to get the flames under control at the property.
A road closure was put in place at 2am at Willesden Lane between Walm Lane junction and Kilburn High Road junction. Motorists are warned this remains in place.
Some firefighters remained at the scene late on Wednesday morning, where part of the first and second floors of the property were damaged along with 70% of the roof.
London Fire Borough Commander for Brent Simon Tuhill reported the incident in Twitter saying there were no reports of anyone being injured.
Dan Brown who lives next door to the derelict house in a flatshare said he and his flatmates were at put at no risk from the fire and their house was not damaged.
The Brigade said the fire was under control at 6.36am.
A spokesperson for the London Fire Brigade said: “A derelict house with two floors was on fire.
“At least 70% of the roof was on fire.
“Six fire engines were sent to the scene and we have two jets still on site."
Fire crews from Willesden, West Hampstead, Park Royal and North Kensington fire stations attended the scene.
The cause of the fire is under investigation.