Revised plans to build a twin tower building at Chiswick Roundabout, which will include 327 flats, have been recommended for refusal.
A report prepared for the planning committee, which will decide the fate of the huge proposal, claims the buildings will add "substantial harm" to heritage in the area including Kew Gardens, conservation areas and listed buildings.
The damning document goes on to state the proposed scheme design is flawed and does not meet the borough's affordable housing needs.
Amendments to the plan include a smaller retail floorspace and a slight increase in office space with the giant LED digital advertising screens reduced from four to three.
"The standard of design proposed would not be outstanding or of the highest quality and the proposed provision of affordable housing at the site would not maximize affordable housing delivery or promote mixed and balanced communities," the planning committee report states.
The previous application was to build 320 new homes with 96 affordable housing units.
More than 17,000 residents were consulted when the application was received and were notified again in November 2016 when the application was amended and further information was submitted.
A total of 687 letters of objection were received and 198 letters of support.
Local groups opposing the proposals are expected to turn up to the planning committee meeting.
West Chiswick and Gunnersbury Society (WCGS) stated it was "pleased" with the recommendation of refusal, claiming the site is unsuitable for residential use and will have a negative impact on traffic, public transport and heritage.
In a statement, WCGS said: "We strongly endorse this recommendation as the proposed scheme would have a seriously detrimental impact on the local economy, environment and the quality of life of existing residents and any future residents of the development."
Marie Rabouhans, chairman of WCGS, said: "The developer submitted amended plans which make only minor changes to the development.
"While we strongly support the grounds for refusal given in the planning officer's report we regret that the grounds given do not include that the constrained site surrounded by major roads in a highly polluted (air and noise) locality is, in principle, totally unsuitable for residential use.
"WCGS believes that any development on this site should be non-residential."
Strand on the Green Residents Association objected the proposed development on the grounds of its height which it says will be "out of character and dominant over the adjacent residential area".
Other reasons for objection included "the bulk of the building is too dense for the area of the site" and "air quality and pollution has not been adequately addressed."
Brentford Community Council has said it is "a poor development location" and the scheme should not be approved.
The proposal by developers Starbones Ltd at Chiswick Roundabout were put on hold in April last year following masses of disapproval from residents.
The site has had many previous planning applications including Tricorn Tower - 42-storey high-rise housing and the controversial giant Octopus office building block.
Now the public will have to wait and see whether the heavily disapproved "Gateway" to the Golden Mile will go ahead or be put down.
The final decision will be announced at Hounslow council's planning committee on Thursday (January 12).
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