Members of Private Tenant's Group in the borough are searching for support to open a not-for-profit agency "to tackle the poor standard of privately rented accommodation in the area".
It comes as a rising number of renters have demanded a basic standard of accommodation as rent prices increase in the NW postcode.
In a recent report carried out by Shelter, it was claimed 69% of privately rented homes in the UK do not meet the newly established "Living Home Standard".
A spokesman for Advice for Renters, a charity which offers housing advice, Katherine Wilson said: "The number of people forced into private renting is soaring and we all know it’s due to lack of social housing and rocketing house prices.
"Buying a home is simply out of reach for most people unless you are lucky enough to inherit wealth.
"Many of the borough’s poorest residents are forced into the worst privately rented accommodation.
"Standards are so low and conditions so hazardous it affects a family health and wellbeing."
Ms Wilson said the main cause of homelessness in Brent is due to eviction from the private rented sector.
"The rising rents mean more and more people face losing their homes," she said.
During the Mayor of London's first ever People's Question Time held at the Brent Civic Centree, Mr Khan was asked by Advice for Renters if he was willing to support the idea before his own plans to tackle the city's housing crisis come to fruition.
The Mayor replied he had been told by London Assembly the borough has some of the worst conditions for damp and the longest wait for getting landlords to repair conditions, but did not say if he could fund the project.
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