Six people have been treated by paramedics and two were trapped on a bus after it crashed into a shop near Clapham Junction.
Emergency services worked to rescue the two passengers stuck on the upper deck following the accident in Lavender Hill, Battersea.
Fire crews used an aerial ladder platform to bring them to safety.
Police were called at around 6.55am on Thursday (August 10) to the junction with Altenburg Gardens, along with two fire engines, three fire rescue units and the London Ambulance Service (LAS).
The driver of the bus has been taken to a south London hospital, while a number of people were treated by LAS at the scene.
Images on social media show the aftermath of the accident, with the shop front and front of the bus destroyed.
Road closures are in place and motorists have been advised to avoid the area.
A statement on the Metropolitan Police website says: "Emergency services at the scene of a collision in Wandsworth.
"Police were called at approximately 06:55hrs on Thursday, 10 August to reports of a bus in collision with a building on Lavender Hill at the junction with Haltenburg Gardens, SW11.
"Officers, the London Fire Brigade and London Ambulance Service are in attendance.
"The driver has been taken to a south London hospital. A number of passengers were treated by LAS at the scene.
"Two passengers remain trapped on the upper deck.
"The road is currently closed to traffic."
A statement from the London Fire Brigade reads: "Two fire engines and three fire rescue units have been called to the scene of a bus which has crashed into a shop front in Lavender Hill in Battersea.
"Firefighters are working to release two people who are trapped on the upper deck of the bus.
"The driver of the bus has been taken to a south London hospital and London Ambulance Service has treated a number of passengers at the scene.
"Local road closures are in places and motorists are advised to avoid the area.
"The Brigade was called at 0655. Fire crews from Battersea, Chelsea, Heston and Croydon are at the scene."
LAS said at 8.30am it had treated six patients following the collision and that crews remained on scene.
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