Snow, sleet and rain forecasts have prompted the Met Office to place a yellow weather warning for London as a frontal band is expected to push across the southern parts of the UK.
The cold temperatures, predicted for Friday (March 4) afternoon and evening, are to bring 200-400m snow to higher ground, with rain and sleet turning into snow briefly for other parts of London.
Wintery conditions have "the potential to result in medium impact on travel", according to the Met.
A chief forecaster for the Met Office said: "Please be aware of the potential for difficult driving conditions and for some travel disruptions on Friday evening rush hour and overnight into Saturday morning."
Meteorologists have also urged people to drive safely as there is a high chance of widespread black ice on the roads.