Tesco is calling time on its Express store in Wealdstone as part a nationwide series of closures.
The convenience store in High Street, Wealdstone, could be closed as early as March 15, after it was included on a list of 43 stores which the supermarket giant is axing nationally.
The company is currently informing staff at the affected stores.
Tesco chief executive Dave Lewis said the decision, which will result in 2,000 job losses across the country, had been "exceptionally difficult". He told the BBC: "Our priority is to explain what this announcement means for our colleagues and, wherever possible, offer them alternative roles with Tesco."
In total, 18 Express, 12 Metro, seven superstores and six Homeplus stores are closing following two years of falling sales and an accounting scandal, which saw the Tesco overstate its profits by some £263million.
Earlier this month we reported how Tesco was scrapping plans for 49 new Tesco Extra stores but that plans for a new supermarket, a hotel and 125 homes at Hillingdon Circus was going ahead.