Westbourne Grove traders are demanding compensation after Thames Water closed the popular shopping street for eight months.
Many shopkeepers on Westbourne Grove, which reopened last Monday, say they face ruin after takings plummeted during lengthy waterworks.
Matt Ukropec, of Electrical Wholesalers, said takings in his shop were down by as much as 80 per cent.
He said: "We were hit badly, as there was a huge crane parked just outside, which was really noisy. People couldn't drive down the road, so they were put off coming to the shop. If business does not pick up soon we may have to close."
Newsagent Rupal Patel, of Bishops Cut Price, said she wants compensation for more than £4,000 lost during the roadworks. She said: "People used to buy bus passes from here, but they stopped coming when the work started.
"It's going to take a long time for customers to start coming back to the shop."
A Thames Water spokesman said the company was not obliged to provide compensation, but would consider offering it to certain shops in Westbourne Grove.
He said: "We'll look at the previous three years' earnings and assess how much effect our work had on their earnings. We're working with individual shop keepers to work out what is a reasonable payment.
"We did everything we could to ensure people were aware of the work before it started, and the project manager held an information session one night a week during the work, where shopkeepers could ask questions."