Figures just released show the borough is likely to be the fourth hardest hit by job losses.
Last week, economic consultancy firm Gauvrin published its 'recession map' detailing which London boroughs would be most affected by the downturn in the economy.
It predicts 1,320 jobs will be axed in Hillingdon by the end of the year.
The borough was ranked fourth behind Westminster (3,579), The City of London (1,485) and Camden (1,347).
James Reed manager of recruitment company Blue Arrow, in High Street, Uxbridge, said: "There's a slight increase in people looking for jobs. There's been a slight drop in jobs available but for the right people with the right skills there are still positions out there."
A spokeswoman for GlaxoSmith-Kline of Stockley Park told the Gazette there had been a small number of redundancies at the site as part of 'streamlining' the company.
Avis' car hire's UK headquarters, in Station Road, Hayes, is also set to close, as part of a cull of 100 jobs in a bid to halt the plunge in profits. Avis was unable to comment by the time the Gazette went to press.
Ian Edwards, head of partnerships and community engagement at Hillingdon Council, said: "Whilst others may be forecasting a higher number of job loses in Hillingdon than the average across London, this does not necessarily mean that the impact on Hillingdon's residents will be worse than elsewhere."
According to the latest figures by official labour market statistics collator Nomis, there are 45,100 people in Hillingdon not working, with 11,500 of those looking for work.
In October there were 3,149 people claiming job seekers' allowance.
Stuart Barber, regional organiser for the trade union Unison, said he knew of no plans for large redundancies, which by law must be flagged up at least 30 days in advance.