Tenants in a Sands End H&F Homes estate are being forced to move out and their 80 homes will be bulldozed.
Hammersmith and Fulham Council rubberstamped the plans on Monday at a cabinet meeting, meaning tenants in Watermeadow Court, Fulham, will have to get out and bid for new rented housing.
Leaseholders will be subject to a compulsory purchase order so the homes, which the council say are too small, can be demolished.
But Julie Frewin, 43, has lived in the 1980s estate for 16 years and is a full-time carer for her disabled son Simon, 21, who was born with a developmental disorder and is autistic.
"My son is happy in this area. This rehousing will unsettle him and he won't be happy," said Mrs Frewin.
Hammersmith and Fulham Council claims it has not yet decided what it will do with the 1.2 acres of prime real estate, which is worth millions of pounds.
Tenants can bid for nearby housing association properties in Imperial Wharf, but Miss Frewin added that she is worried about the rental cost, which is more than £80 per month higher.
"My neighbours and I are all going to be separated from each other," she added.
It will cost 6.5million to move the tenants from their homes.
The three blocks that are earmarked for demolition include Charlow Close, Potters Road, Townmead Road and Watermeadow Lane.
Cllr Lucy Ivimy, the Cabinet Member for Housing, said: "This is an exciting scheme that is going ahead with full consultation of leaseholders and tenants.
"It is clear that people were living in cramped and uncomfortable conditions in Watermeadow Court."