The Central Line is set to be affected by a strike on Friday when union members walkout in a dispute over working conditions.
The ASLEF union said a massive 90 per cent of members backed the strike over the way London Undergroud "fails to treat drivers with the respect and dignity they deserve".
"This dispute has been brought about by management intransigence on a range of issues, but at its heart is management’s refusal to treat drivers with the respect and dignity they deserve at work," said Finn Brennan, an organiser for the union.
"Our members will not tolerate a situation where vulnerable people leave sickness review meetings in tears and drivers with years and years of good and long service are threatened with disciplinary action for a delay of 33 seconds in leaving a terminus."
Transport for London has not yet confirmed how widespread the disruption will be.
Stations from West Ruislip, through South Ruislip and on to Northwood and Ealing could be affected.
The London Underground says it is in talks with ASLEF about the issues which have been raised.
"We’re disappointed that ASLEF members have voted in favour of strike action while discussions are still ongoing," said a London Underground spokesman.
"Strike action is not necessary and we urge them to continue talks with us to understand and resolve their concerns."
Nigel Holness, London Underground’s Operations Director, said: “Should Friday’s strike go ahead there will be disruption on both the Central and Waterloo & City lines.
"We will have staff and volunteers across the network to help customers with their journeys but I advise people to plan ahead and check before they travel. All other Tube, DLR and London Overground routes will be operating as normal."
Meanwhile, the Metropolitan and Piccadilly lines from Uxbridge are back up and running now improvement works are complete.
See our gallery of photos of the work .