Some residents of Hanwell are up in arms over plans which they say will spoil an area and create traffic chaos.
Developer Frendcastle has submitted wants to build more than 121 homes - 72 private and 49 'affordable' - in three buildings on the site of the former Booker warehouse in Trumpers Way.
The scheme includes four industrial units and an underground car park for at least 125 vehicles.
But some locals are not happy. Sidney Carter of Olde Hanwell Residents' Association said: "We've decided that we are going to oppose the present planning application.
"This proposal is for a conservation area and the buildings are completely out of character with the site."
Mr Carter, who said he represents residents of Osterley Park View Road, said if approved, the scheme would produce a glut of heavy goods vehicles.
Bill Bailey, development manager at Frendcastle said: "This proposal is being considered by the planning authority, which will consider all the various factors when making a decision.
"It's very hard to say whether something is out of character when it is an area which combines Victorian housing with industrial units. It's very mixed.
"I don't think it's out of character. "It's more a question of whether or not it will impact on the local environment.
"As regards traffic and parking, this is a technical issue and as such we are having independent assessments done.
"The benefits of this scheme are that it will tidy up what is presently quite a poor environment and provide much-needed affordable housing."
Mr Bailey expects the proposal to be considered by Christmas.